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Perth researchers one step closer to wiping out childhood ear infections
Wiping out childhood ear infections
Spritz-OM
Ear Infections
Wesfarmers Centre of Vaccines & Infectious Diseases
ATOMIC Ears Study
Team
Bacterial Respiratory Infectious Disease Group (BRIDG) projects
Past projects
Reports and Findings
Safety, tolerability, and effect of a single aural dose of Dornase alfa at the time of ventilation tube surgery for otitis media: A Phase 1b double randomized control trial
One third of children require repeat ventilation tube insertion (VTI) for otitis media. Disease recurrence is associated with persistent middle ear bacterial biofilms. With demonstration that Dornase alfa (a DNase) disrupts middle ear effusion biofilms ex vivo, we identified potential for this as an anti-biofilm therapy to prevent repeat VTI. First, safety and tolerability needed to be measured.
Published research Ear Infections Child Disability Ear Health Vaccine Trials Group Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Bacterial Respiratory Infectious Disease GroupThe Respiratory Microbiome in Paediatric Chronic Wet Cough: What Is Known and Future Directions
Chronic wet cough for longer than 4 weeks is a hallmark of chronic suppurative lung diseases, including protracted bacterial bronchitis, and bronchiectasis in children. Severe lower respiratory infection early in life is a major risk factor of PBB and paediatric bronchiectasis.
Published research Subsite: Wesfarmers Centre of Vaccines and Infectious Diseases Bacterial Respiratory Infectious Disease Group Wet Cough Respiratory viral infections Lung functionEgg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth
IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.
Published research Pregnancy and Early Life Immunology Nutrition in Early Life ORIGINS Bacterial Respiratory Infectious Disease GroupThe SPEC score—A quantifiable CT scoring system for primary ciliary dyskinesia
Structural lung changes seen on computed tomography scans in persons with primary ciliary dyskinesia are currently described using cystic fibrosis derived scoring systems. Recent work has shown structural changes and frequencies that are unique to PCD, indicating the need for a unique PCD-derived scoring system.
Cystic Fibrosis Published research Bacterial Respiratory Infectious Disease Group Subsite: Walyan Child and adolescent health