Ingrid Pat Laing Holt IL PG BSc PhD PhD, DSc, FRCPath, FRCPI, FAA Honorary Research Fellow Emeritus Honorary Researcher 6319 1828 Ingrid.laing@telethonkids.org.au@hotmail.cmo Patrick.Holt@telethonkids.org.au Honorary Research Fellow Emeritus ...

• 1. Telethon Kids Institute
• Projects

Chronic innocuous aeroallergen exposure attenuates CD4+ T cell-mediated airways hyperresponsiveness in mice; however, the mechanism(s) remain unclear ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• August 2011

Asthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• May 2011

With the emergence of allergic and autoimmune diseases in populations that have started to transit to a western lifestyle, there has been an increasing... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• December 2010

IgE antibodies in house dust mite (HDM) allergy follow a predictable pattern. Half are directed against two dominant allergens and the remainder largely against ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• July 2010

Early immunological influences on asthma development: opportunities for early intervention ...

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• Our research
• Reports and Findings
• 2010
• January 2010

This study investigated the potential role of ST2 in children with acute asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• March 2009

Deborah Pat Strickland Holt DH PG PhD PhD, DSc, FRCPath, FRCPI, FAA Program Head, Immunobiology and Immunotherapeutic Program Emeritus Honorary Researcher Deb.Strickland@telethonkids.org.au Patrick.Holt@telethonkids.org.au Program Head, ...

• 1. Telethon Kids Institute
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• Human Immunology

Patients with comorbid asthma-obesity experience greater disease severity and are less responsive to therapy. We have previously reported adipose tissue within the airway wall that positively correlated with body mass index. Accumulation of biologically active adipose tissue may result in the local release of adipokines and disrupt large and small airway function depending on its anatomical distribution. This study therefore characterized airway-associated adipose tissue distribution, lipid composition, and adipokine activity in a porcine model. ...

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• 2023
• February 2023

Excessive production, secretion, and retention of abnormal mucus is a pathological feature of many obstructive airways diseases including asthma. Azithromycin is an antibiotic that also possesses immunomodulatory and mucoregulatory activities, which may contribute to the clinical effectiveness of azithromycin in asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without? ...

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• Our research
• Reports and Findings
• 2022
• July 2022

To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018