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        Assessment of early bronchiectasis in young children with cystic fibrosis is dependent on lung volume

        The aim of this study was to determine whether assessment of early CT scan-detected bronchiectasis in young children with cystic fibrosis (CF) depends on... ...

        Research

        Novel end points for clinical trials in young children with cystic fibrosis

        Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality. ...

        Research

        Bronchial brushings for investigating airway inflammation and remodelling

        Asthma is the commonest medical cause for hospital admission for children in Australia, affects more than 300 million people worldwide, and is incurable... ...

        Research

        Of pigs, mice, and men: Understanding early triggers of cystic fibrosis lung disease

        Understanding early triggers of Cystic Fibrosis Lung Disease ...

        Research

        Airway surface liquid pH is not acidic in children with cystic fibrosis

        Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

        Research

        Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

        These findings indicate that early CF lung disease is characterized by an increased mucus burden and inflammatory markers without infection or structural lung disease ...

        Research

        The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

        Pulmonary inflammation in surveillance bronchoalveolar lavage has a cumulative effect on structural lung disease extent, more so than infection ...

        Research

        The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

        Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease ...

        Research

        Elucidating the interaction of CF airway epithelial cells and rhinovirus: Using the host-pathogen relationship to identify future therapeutic strategies

        A better understanding of the innate immune responses by CF airway epithelial cells is needed to identify why viral infections are more severe in CF ...

        Research

        Anaesthesia, pain and recovery profiles in children following dental extractions

        The aim of this prospective cohort study was to describe the anaesthetic practices, rates of postoperative pain and the recovery trajectory of children having urgent dental extractions at our institution. ...

        Research

        Determinants of culture success in an airway epithelium sampling program of young children with cystic fibrosis

        Determinants of culture success through retrospective analysis of a program of routinely brushing children with Cystic Fibrosis airway disease ...

        Research

        Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

        To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls. ...

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