Cancer Centre
Unlocking the key to leukaemia progression in kids
Team
Leukaemia Translational Research projects
Reports and Findings
The critical role of the bone marrow stromal microenvironment for the development of drug screening platforms in leukemia
Extensive research over the past 50 years has resulted in significant improvements in survival for patients diagnosed with leukemia. Despite this, a subgroup of patients harboring high-risk genetic alterations still suffer from poor outcomes. There is a desperate need for new treatments to improve survival, yet consistent failure exists in the translation of in vitro drug development to clinical application.
Children's Cancers Published research Leukaemia Translational ResearchPharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia
PEGasparaginase is known to be a critical drug for treating pediatric acute lymphoblastic leukemia (ALL), however, there is insufficient evidence to determine the optimal dose for infants who are less than one year of age at diagnosis. This international study was conducted to identify the pharmacokinetics of PEGasparaginase in infants with newly diagnosed ALL and gather insight into the clearance and dosing of this population.
Children's Cancers Published research Early Childhood Development Leukaemia Translational ResearchFDA-approved disulfiram as a novel treatment for aggressive leukemia
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach.
Children's Cancers Published research Leukaemia Translational ResearchInflammation induces α1-adrenoceptor expression in peripheral blood mononuclear cells of patients with complex regional pain syndrome
Persistent regional and systemic inflammation may promote pain and hyperalgesia in complex regional pain syndrome. In this study, we investigated whether stimulation of α1-adrenoceptors on peripheral blood mononuclear cells might contribute to this inflammatory state.
Published research Pregnancy and Early Life Immunology Leukaemia Translational Research Subsite: Cancer