Contact us
Please direct general enquiries to our reception on (08) 6319 1000.
For further information about our laboratory equipment, please contact:
Tamara Abel
Microscopy and Equipment Specialist
Phone: (08) 6319 1440
Email: Tamara Abel
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The Telethon Kids Institute is equipped with a diverse range of histology and microscopy equipment and analysis software to facilitate state-of-the-art imaging and study of intracellular organelles, cells and tissue.
Bright Blue Cancer Analysis Suite
Generously supported by donations from Bright Blue, the Institute provides a suite of equipment encompassing all aspects of tissue processing for histology and pathology and enabling a wide range of microscopy applications including transmitted light (brightfield, phase contrast, differential interference contrast (DIC) and fluorescence-based techniques such as epifluorescence (with spectral unmixing capabilities) and confocal.
We also have capabilities to allow live cell time-lapse microscopy for short-(hours) or long- (days) term experiments. Together, this equipment enables our researchers to visualise cells or tissue to study cell function and how they are affected by changing environmental, physiological and disease conditions such as cancer.
The facility incorporates a range of manual and automated histology and pathology instruments including:
Confocal microscopy is an imaging technique which increases optical resolution and contrast by the use of a small pinhole which collects light only from the plane of focus, eliminating ‘out of focus’ glare and enabling the collection of serial optical sections from thick specimens. Telethon Kids Institute houses a Nikon C2+ system enabling multimode (three colour confocal, transmitted light DIC, epifluorescence imaging), multipoint and time lapse imaging.
Features
The Pannoramic MIDI is a digital slide scanner enabling brightfield and fluorescence imaging of up to 12 slides in one run to facilitate rapid, automated imaging and analysis of whole tissue sections.
Features
The Nuance imaging system is a multispectral imaging system enabling quantitation of multiple molecular markers (fluorescence and brightfield) in a tissue section. The system produces clear and accurate images of individual labels on a multi label-tissue section.
The system can therefore be used to for multiplexing and spectral unmixing enabling imaging of multiple fluorescent and chromagen simultaneously together with the removal of any autofluorescence from an image.
This enables researchers to assess changes in cell function by facilitating rapid assessment of gene or protein expression in normal or unhealthy tissue sections.
Features
The Mantra imaging system is a multispectral imaging system enabling quantitation of multiple molecular markers (fluorescence and brightfield) in a tissue section. The system produces clear and accurate images of individual labels on a multi label-tissue section.
The system can therefore be used to for multiplexing and spectral unmixing enabling imaging of multiple fluorophores and chromogens simultaneously, together with the removal of any autofluorescence from an image. This enables researchers to assess changes in cell function by facilitating rapid assessment of gene or protein expression in normal or unhealthy tissue sections.
Features
Live cell imaging and analysis system that enables automated quantification of cell behaviour over time. It is a powerful tool for enabling assessment of cell health, viability, function, and interactions in real time.
The system can be used for a wide range of applications including analysis of 3D spheroids, angiogenesis, apoptosis, proliferation, chemotaxis, cytotoxicity, proliferation, scratch wound analysis, dilution cloning, stem cell monitoring, transfection efficiency and neurite dynamics.
Applications include:
Please direct general enquiries to our reception on (08) 6319 1000.
For further information about our laboratory equipment, please contact:
Tamara Abel
Microscopy and Equipment Specialist
Phone: (08) 6319 1440
Email: Tamara Abel